Therapy of acute leukemia by whole-body irradiation and bone marrow transplantation from an identical normal twin.
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چکیده
منابع مشابه
Treatment of non-Hodgkin's lymphoma with marrow transplantation in identical twins.
Eight patients with disseminated non-Hodgkin's lymphoma who failed conventional combination chemotherapy were treated with high-dose chemotherapy, a supralethal dose of total-body irradiation, and a bone marrow transplant from a normal identical twin. Seven patients experienced complete remission. Four of the seven patients (two with diffuse poorly differentiated lymphocytic lymphoma, one with ...
متن کاملFractionated total body irradiation and high-dose VP 16-213 followed by allogeneic bone marrow transplantation in advanced leukemias.
Thirty-eight patients (median age, 21 years) with acute nonlymphoblastic leukemia (ANLL) (17 patients), acute lymphoblastic leukemia/lymphoma (ALL) (18 patients), chronic myelogenous leukemia (two patients), and refractory anemia received allogeneic bone marrow transplants from HLA-identical sibling donors or a one-antigen-mismatched brother (one patient) after a preparatory regimen consisting ...
متن کاملAllogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia in First Remission: A Randomized Trial of a Busulfan-Cytoxan Versus Cytoxan-Total Body Irradiation as Preparative Regimen: A Report From the Groupe d’Etudes de la Greffe de Moelle Osseuse
From October 1987 to December 1990, 101 patients with acute myeloid leukemia (AML) were randomized to be transplanted in first complete remission (CR1). Preparative regimen including Cytoxan (120 mg/kg) with total body irradiation (CYTBI) (N = 50) or busulfan (16 mg/kg) (BUSCY) (N = 51) was followed by allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling. Mean time between...
متن کاملAllogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase.
Eight patients with Ph1-positive chronic myelogenous leukemia (CML) in chronic or accelerated phase received high-dose cyclophosphamide, total body irradiation, and bone marrow transplantation from an HLA-identical sibling donor. All patients had prompt engraftment and achieved complete hematologic remission. Six patients remain alive and in continuous remission with a normal bone marrow karyot...
متن کاملBone marrow transplantation for refractory acute leukemia in 34 patients with identical twins.
Thirty-four patients aged 4-67 yr (median 17) with acute lymphocytic leukemia (ALL) (18 patients) or acute nonlymphocytic leukemia (ANL) (16 patients) who failed to enter complete remission (CR) or relapsed on conventional chemotherapy were treated with cyclophosphamide (CY), 60 mg/kg/day for 2 days, 1000 rad total body irradiation, and a marrow transplant from a genotypically identical normal ...
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عنوان ژورنال:
- Blood
دوره 14 3 شماره
صفحات -
تاریخ انتشار 1959